About Dimethindene Maleate A first generation histamine H1 antagonist, Antipruritic, anti-allergic agent. Mechanism of Action of Dimethindene Maleate This drug blocks the receptors of histamine (H1 receptors) centrally and peripherally. This results the inhibition of activation and allergic symptoms produced by histamines. The drug also have some antimuscarinic and serotonic receptor antagonistic action Indications for Dimethindene Maleate 1. Allergic dermatitis 2. Pruritis 3. Ocular allergies 4. Urticaria 5. Angioedema 6. Rhinitis 7. Conjunctivitis