About Cefuroxime Second Generation Cephalosporin antibiotic. Mechanism of Action of Cefuroxime Cefuroxime is a 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefuroxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefuroxime Indications for Cefuroxime 1.Meningitis caused by H.influenzae, meningococci, pneumococci etc. 2.Gonorrhea 3.Pneumonia & Pulmonary infections 4.Infections caused by ampicillin resistant H. influenzae 5.Septicemia 6.Tonsillitis 7.Pharyngitis 8.Urinary tract infections 9.Otitis media