About Dorzolamide Carbonic anhydrase inhibitor, Thiophene derivative, a sulfonamide, Antiglucoma. Mechanism of Action of Dorzolamide Dorzolamide is a sulfonamide used as topical carbonic anhydrase inhibitor. Inhibition of carbonic anhydrase-2 in ciliary processes of eye leads to reducing intra ocular tension by decreasing aqueous humor secretion by slowing the formation of bicarbonate ions with subsequent decrease in sodium and fluid transport. Indications for Dorzolamide 1. Ocular hypertension 2. Open angle glaucoma Interactions for Dorzolamide Similar to diuretics (carbonic anhydrase inhibitor) ? as possibility of systemic absorption after topical administration.