About Duloxetine A serotonin-norepinephrine reuptake inhibitor,Thiophene derivative, Antidepressant. Mechanism of Action of Duloxetine Duloxetine preferentially inhibits the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitter Serotonin in the synaptic cleft and produces antidepressant effect Indications for Duloxetine 1. Major depressive disorder 2. Diabetic Peripheral Neuropathic Pain 3. Generalised anxiety disorder Typical Dosage for Duloxetine Major Depressive Disorder: 20 - 60mg / day in 2 divided doses Diabetic Peripheral Neuropathic Pain:60 mg/day Generalized Anxiety Disorder: 60 mg/ day