About Salicylic Acid A beta hydroxy acid, Keratolytic, Topical Skin Product(Anti Acne). Mechanism of Action of Salicylic Acid It is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle. For milder acne, salicylic acid helps unclog pores to resolve and prevent lesions.