About Benzocaine Ester Local Anesthetic Mechanism of Action of Benzocaine It binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. This results the blocking of depolarization of the neuronal membrane and initiation and conduction of nerve impulses at the site where it applies. Indications for Benzocaine 1.Local anaesthetic agent 2.Topical Analgesics Typical Dosage for Benzocaine Topical- Dental pain and dental procedures- Adults and children- 20% gel or paste to area whenever necessary Pruritic conditions- Adult- 1%- 20% topical preparation to the affected area 3 to 4 times daily Otitis media and other forms of otitis- Adults- 4 to 5 drops in external auditory canal- repeat every 1 to 2 hour Sore throat pain- Adults and children (>3 years) - 3:1 lozenge whenever necessary Slowly dissolved in the mouth Male genital desensitization- Adults- 3 to 7.5 % (water soluble base) topical prep