About Salicylic Acid A beta hydroxy acid, Keratolytic, Topical Skin Product(Anti Acne). Mechanism of Action of Salicylic Acid It is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle. For milder acne, salicylic acid helps unclog pores to resolve and prevent lesions. Indications for Salicylic Acid 1.Treats skin irritation and inflammation caused by burns, insect bites, fungal infections, and eczema.