About Cefadroxil First Generation Cephalosporin, para-hydroxy derivative of cefalexin, Oral broad-spectrum antibiotic Mechanism of Action Cefadroxil is a 1st generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefadroxil inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefadroxil Indications for Cefadroxil 1. Urinay tract infections 2. Tonsillitis & Pharyngitis 3. Skin &soft tissue infections 4. Otitis media. Contra-indications of Cefadroxil 1.Hypersensitivity to cephalosporins 2.Porphyria 3.Neuromuscular disorders.