About Fluvastatin HMGCoA reductase inhibitor,Statins,Antilipemi agent Mechanism of Action of Fluvastatin Fluvastatin selectively and competitively inhibits the hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate, the rate-limiting step in cholesterol biosynthesis. Inhibition results in a decrease in hepatic cholesterol levels which stimulates the synthesis of LDL receptors and increases hepatic uptake of LDL cholesterol. The end result is decreased levels of plasma total and LDL cholesterol. Indications for Fluvastatin 1.Hyperlipidaemias 2.Hypercholesterolaemia 3.Atherosclerosis