This medication is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is also used with other medications to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions). Hydrocortisone suppositories help to relieve rectal pain, itching, bloody diarrhea, and bleeding by reducing swelling (inflammation) directly in the rectum and anus. Hydrocortisone belongs to a class of drugs called corticosteroids. hydrocortisone acetate rect may interact with the following medications Severe Interactions of hydrocortisone acetate rect: These medications are not usually taken together. IMMUNOSUPPRESSIVES- IMMUNOMODULATORS SYSTEMIC CORTICOSTEROIDS/LIVE VACCINES CORTICOSTEROIDS- CORTICOTROPIN (ACTH)/AMPHOTERICIN B GLUCOCORTICOIDS/ALDESLEUKIN CORTICOSTEROIDS/MIFEPRISTONE CORTICOSTEROIDS/SELECTED ANTICHOLINESTERASE