About Clopidogrel Thienopyridine class, Platelet Aggregation Inhibitor, Antithrombic, Anti platelet agent. Mechanism of Action of Clopidogrel The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It alters surface receptors in platelets and inhibits ADP induced platelet-fibrinogen and platelet-platelet binding and prevents platelet aggregation. It blocks G-protein coupled P2YAC type of inhibitory purinergic receptors which mediates adenylyl cyclase inhibition by ADP. It prolongs bleeding time. Indications for Clopidogrel 1. To reduce atherosclerotic events 2. Thrombotic disorders 3. Prevention of stroke 4. Prophylaxis of myocardial infarction 5. Peripheral vascular diseases 6. Coronary artery diseases.