About Indapamide Thiazide-related(a non-thiazide sulphonamide) drug, Diuretic, Antihypertensive. Mechanism of Action of Indapamide It exerts thiazides like diuretic action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion. It causes vasodilatation by Ca channel blockade. It decreases total peripheral resistance and exerts anti hypertensive action. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure. Indications for Indapamide 1. Hypertension 2. Oedema Interactions for Indapamide Diazoxide: Synergistic action - may cause hyperglycemia, hyperuricaemia and hypotension.